Pharmacokinetic studies of commercially available curcumin formulations in healthy humans: A systematic comparison with novel highly bioavailable curcuRouge® formulation

Συγγραφείς

  • Mahendra Kapoor
  • Tadashi Hashimoto
  • Yasuhiro Katsuura
  • Hiroki Aoyama
  • Kanako Tanigaki
  • Atsuhiro Kishimoto

DOI:

https://doi.org/10.31989/ffs.v5i12.1869

Περίληψη

Curcumin has been widely studied for its therapeutic potential, but its clinical efficacy is limited by poor bioavailability. Various strategies have been developed to enhance curcumin absorption. 

      This systematic review evaluated the pharmacokinetic performance of commercially available absorption-enhanced curcumin formulations by comparing their AUC0-t and Cmax values, normalized per milligram of curcumin, against unformulated standard extracts.

       Among the formulations analyzed, curcuRouge®, an amorphous curcumin formulation, demonstrated the highest absorption (AUC0-t: 17.23 ng/mL·h) and peak concentration (Cmax: 5.47 ng/mL), significantly outperforming others (P < 0.05). CurQfen® (9.86 ng/mL·h) and NovaSol® (10.91 ng/mL·h) showed similar but lower absorption than curcuRouge®. Relative to unformulated curcumin, curcuRouge® showed a 162.7-fold increase in bioavailability, making it approximately 1.7 and 1.6 times more bioavailable than NovaSol® and CurQfen®, respectively. In terms of Cmax, curcuRouge® was 182.0-fold higher than NovaSol® (96.5-fold) and CurQfen® (116.5-fold), indicating it is 1.9 and 1.6 times more absorbable, respectively. 

        These findings suggest that curcuRouge® represents a significant advancement in curcumin delivery with its amorphous structure and enhanced dissolution rate. This analysis offers a robust comparative framework for evaluating bioavailability in commercial curcumin formulations and highlights curcuRouge® as a promising option for improved therapeutic efficacy.

Highlights:

  1. Curcumin’s therapeutic use is limited due to poor bioavailability.
  2. Study compares the pharmacokinetics of absorption-enhanced curcumin formulations.
  3. Amorphous structure promotes curcuRouge® stability, solubility and absorption efficiency.
  4. curcuRouge® showed excellent bioavailability than other curcumin formulations at modest doses.

Keywords: curcumin; Curcuminoids; amorphous; curcuRouge®, human, pharmacokinetics, bioavailability.

Λήψεις

Δημοσιευμένα

2025-12-26

Τεύχος

Τόμ. 5 Αρ. 12 (2025): December 2025

Ενότητα

Review Articles

Άδεια

Πνευματική ιδιοκτησία (c) 2025 Mahendra Parkash Kapoor, Tadashi Hashimoto, Yasuhiro Katsuura, Hiroki Aoyama, Kanako Tanigaki, Atsuhiro Kishimoto

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