Nutrigenomics of Neuradaptogen Amino-Acid-Therapy and Neurometabolic Optimizers: Overcoming carbohydrate bingeing and overeating through neurometabolic mechanisms

Authors

  • Kenneth Blum Department of Psychiatry, University of Florida, College of Medicine, Mcknight Brain Institute, Gainesville, Florida
  • Debasis Bagchi Innovative Research and Clinical Trials, Iovate Inc., Toronto
  • Abdalla Bowirrat Clinical Neuroscience and Population Genetics, Ziv Government Medical Center
  • B. William Downs Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
  • Roger L. Waite Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
  • John Giordano Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach
  • Siohban Morse Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach
  • Margaret Madigan Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
  • Jaclyn M. Downs Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California
  • Eric R. Braverman Department of Clinical Neurology, Path Foundation NY, New York, New York
  • Margaret Polanin Department of Neurological Surgery, Weill Cornell College of Medicine, New York, New York
  • Debmayla Barh Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172
  • Frank Fornari Dominion Diagnostics Inc. North Kingstown, Rhode Island
  • Thomas Simpatico Community Mental Health Institute, Center for Clinical & Translational Science, University of Vermont and Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont

DOI:

https://doi.org/10.31989/ffhd.v1i9.121

Abstract

Despite progress that has been made in the treatment of obesity, the epidemic continues to rise worldwide. While pharmacological treatment of obesity may be effective, medications may have significant side effects and can be potentially fatal. This review will provide significant evidence to substantiate the existence of Reward Deficiency Syndrome in Obesity and the role of catecholaminergic pathways in aberrant substance seeking behavior, in particular cravings for carbohydrates. The genetic basis for generalized craving behavior will be established. Evidence to support the augmentation of precursor amino acid therapy and enkephalinase, MOA and COMT inhibition leading to enhanced levels of neurotransmitters: serotonin, enkephalins, GABA and dopamine/norepinephrine as well increasing insulin sensitivity (affecting dopamine neuronal synthesis regulation) through the use of certain neurometabolic optimizers will also be provided. This review article cites many published studies to support a conceptual paradigm shift towards the use of this proposed nutrigenomic formula. The analysis and research preceding this formulation is outlined. This formulation has a generalized anti-craving effect and can inhibit carbohydrate bingeing, inducing significant healthy fat loss and prevention of relapse. This is the first time that components of this formula have been combined, at the dosage levels indicated with the goal of promoting successful and sustainable body recomposition. We are encouraging other laboratories to further evaluate Neuroadtagen Amino-Acid Therapy (NAAT)/Nurometabolic optimizers as a putative anti-obesity complex in larger controlled blinded studies and await interpretation of must these needed studies.

Keywords: NAAT, Dopamine, Genes, Polymorphisms, Obesity, Craving Behavior, Overeating, Reward Deficiency Syndome, Nutrigenomics.

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Published

2011-09-29

Issue

Vol. 1 No. 9 (2011): September 2011

Section

Review Articles

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