Cancer-specific Therapeutic Potential of Resveratrol: Metabolic Approach against Hallmarks of Cancer
Cancer hallmarks include evading apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis. Cancer cells undergo metabolic reprogramming and inevitably take advantage of glycolysis to meet the increased metabolic demand: rapid energy generation and macromolecular synthesis. Resveratrol, a polyphenolic phytoalexin, is known to exhibit pleiotropic anti-cancer effects most of which are linked to metabolic reprogramming in cancer cells. This review summarizes various anti-cancer effects of resveratrol in the context of cancer hallmarks in relation to metabolic reprogramming.
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Copyright (c) 2013 Dong Hoon Suh, Mi-Kyung Kim, Hee Seung Kim, Hyun Hoon Chung, Yong Sang Song
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