Serum levels of vitamin D, calcium, phosphorus, and oxidative parameters in healthy and diabetic people
Introduction: Diabetes mellitus is a metabolic disease that is a primary public health consideration. Low Vitamin D levels are linked to type 2 diabetes (T2DM), diminished insulin release, and enhanced insulin resistance in humans and animals. Vitamin D is also involved in the regulation of calcium and phosphorus homeostasis. Oxidative stress and antioxidant imbalances are important for the progression of diabetes as well. In this endeavor, the levels of vitamin D, calcium, phosphorus, and evaluation of the oxidant- antioxidant factors of malondialdehyde (MDA) and total antioxidant capacity (TAC) in healthy and diabetic people were compared.
Methods: This descriptive-analytical study was conducted in 2020 in Shiraz, Fars province, Iran. The population included 40 T2DM patients (with HbA1c equivalent 6-8) without comorbidities, 20-60 years old for both genders, and 40 healthy individuals (female and male between 20-60 years old without comorbidities). The high-performance liquid chromatography (HPLC) method was adopted for measuring Vitamin D and for measuring other levels, the colorimetric method was used. Using SPSS 22, statistical analysis was performed. The Mann- Whitney U test for quantitative data was applied. P<0.05 was deemed significant.
Results: There was a statistically significant difference between the two groups when it came to the means of vitamin D and MDA. In the diabetic group, vitamin D levels were lower (p=0.001) and MDA levels were higher (p<0.001). Comparing the level of calcium and phosphorus in diabetics and healthy people revealed no significant difference. This result was also true for the TAC test.
Conclusions: According to our results, the mean of vitamin D in T2DM was significantly lower than healthy people and MDA in T2DM significantly increased compared to the control group, suggesting that increasing the activity of this enzyme in the development of secondary complications in diabetic patients is a predisposing factor.
Keywords: Vitamin D, Diabetes mellitus, HPLC, Oxidative stress
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