Anti-cancer effect of EGCG and its mechanisms
Epidemiological analysis demonstrated there are negative correlation between green tea consumption and the risk of non-Hodgkin lymphoma1 and prostate cancer. Recent studies show (–)-epigallocatechin-3-O-gallate (EGCG), major green tea polyphenol suppresses the proliferation of cancer cells and induces cell death without adversely affecting normal cells. Several molecular mechanisms of its effect have been suggested. Recently, 67-kDa laminin receptor (67LR) was identified as the sensing molecule for EGCG. Surprisingly, 67LR overexpresses in cancer cells play the crucial role in the selective toxicity of EGCG. Moreover, possible downstream mechanisms were suggested in 67LR-dependent the anti-cancer effect of EGCG. This review focused on the molecular mechanism of EGCG and the novel strategy to amplify its effect.
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Copyright (c) 2016 Motofumi Kumazoe, Hirofumi Tachibana
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