Regenerative collagen and microcirculation enhancement of skin health by patented fermented nutraceutical: in vitro data and potential from a preliminary pilot clinical trial
DOI:
https://doi.org/10.31989/bmp.v3i6.2019Abstract
Background: Skin senescence is a multifaceted process that results from biological aging and exposure to various environmental factors (e.g., smoking, pollution, UV radiation, outer infections, climate change). In addition, skin health is clearly relevant to beauty care, especially—but not exclusively—in women. This has led to the creation of many skincare treatments that lack a rigorous scientific basis.
Objective: We aimed to study a patented fermented papaya preparation (FPP®) through in vitro testing and an in vivo pilot study and determine its measurable effects on collagen and the functional characteristics of skin.
Methods: Human fibroblasts were subjected to UV irradiation either alone or with FPP® to test collagen production and matrix metallo proteinase (MMP) gene expression. A placebo-controlled clinical study (FPP® vs. dextrose-cellulose: 4.5g twice a day for 3 months) was conducted with 26 women (42–56 years old). The clinical parameters tested were elasticity, moisture, trans-epidermal water loss, glow, and microcirculation.
Results: FPP® proved to significantly increase collagen synthesis and protect skin from MMP upregulation in in vitro testing. On a clinical level, it improved all clinical variables tested at a 3-month observation.
Novelty of the Study: This study synergized the objective basic science and the related clinical benefits of FPP® intervention in skin aging.
Conclusions: Although limited data and limited observation time have been accumulated so far, our study suggests that the oral administration of a long-fermentation-processed papaya preparation may be of interest in an interventional strategy for skin aging.
Keywords: collagen synthesis, UVB-elicited MMPs upregulation, elasticity, moisture, trans-epithelial water loss, skin microcirculation, skin glowing, antioxidant capacity, skin texture, skin aging
Downloads
Published
Issue
Section
License
Copyright (c) 2026 BMP/Bioactive Molecules and Pharmaceuticals
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Any manuscripts or substantial parts of it, submitted to the journal must not be under consideration by or previously published in any other journal or citable form. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights or the rights of a third party. In submitting one's article in any form, the author has assigned the FFC publishing rights and has agreed to an automatic transfer of the copyright to the publisher. This is so that the FFC may create print option journals, for example, at the FFC’s discretion. If the author wishes to distribute their works by means outside of the FFC, for example within their community, they will have to place a request.
Correspondence concerning articles published in Functional Foods in Health and Disease is encouraged. While derivative works (adaptations, extensions on the current work, etc.) are allowed, distribution of the modified material is not allowed without permission from the FFC.
