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<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
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<text:span>FFHD</text:span>
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<text:span>Page
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213 of 221 </text:span>
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<text:span>Review Article </text:span>
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<text:span>Open Access </text:span>
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<text:span>Can functional foods reduce the risk of disease? Advancement </text:span>
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<text:span>of functional food definition and steps to create functional </text:span>
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<text:span>food products </text:span>
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<text:span>Danik Martirosyan</text:span>
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<text:span>1,2*</text:span>
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<text:span>, Hunter Kanya</text:span>
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<text:span>2,3</text:span>
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<text:span>Camila Nadalet</text:span>
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<text:span>2,4</text:span>
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<text:span>1</text:span>
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<text:span>Functional Food Institute, San Diego, CA, USA </text:span>
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<text:span>2</text:span>
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<text:span>Functional Food Center Inc., Dallas, TX, USA </text:span>
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<text:span>3</text:span>
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<text:span>University of Colorado-</text:span>
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<text:span>Denver, Denver, Colorado, USA </text:span>
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<text:span>4</text:span>
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<text:span>Foods and Nutritional Sciences, San Diego State University, San Diego, CA, USA </text:span>
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<text:span>*Corresponding author: </text:span>
<text:span>Danik Martirosyan, PhD, Functional Food Institute, San Diego, CA, USA </text:span>
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<text:span>Submission Date:</text:span>
<text:span> March 10</text:span>
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<text:span>th</text:span>
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<text:span>, 2021; </text:span>
<text:span>Acceptance Date:</text:span>
<text:span> May 7</text:span>
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<text:span>th</text:span>
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<text:span>, 2021; </text:span>
<text:span>Publication Date: </text:span>
<text:span>May 10</text:span>
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<text:span>th</text:span>
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<text:span>, 2021</text:span>
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<text:span>Please
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cite
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this
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as:</text:span>
<text:span>
<text:s></text:s>
Martirosyan
<text:s></text:s>
D.,
<text:s></text:s>
Kanya
<text:s></text:s>
H.,
<text:s></text:s>
Nadalet
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C.
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Can
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functional
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foods
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reduce
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the
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risk
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of
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disease? </text:span>
</text:p>
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<text:span>Advancement of functional food definition and steps to create functional food products. </text:span>
<text:span>Functional Food in Health </text:span>
</text:p>
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<text:p>
<text:span>and Disease</text:span>
<text:span> 2021. 11(5): 213-221. DOI: https://www.doi.org/10.31989/ffhd.v11i5.788 </text:span>
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<text:span>ABSTRACT</text:span>
<text:span> </text:span>
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<text:span>The </text:span>
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<text:span>definition </text:span>
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<text:span>of </text:span>
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<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
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<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(FFs) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>has </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been </text:span>
</text:p>
</draw:text-box>
</draw:frame>
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<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>development </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>many </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>years </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>by </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
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</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
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<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Scientists
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
Functional
<text:s></text:s>
Food
<text:s></text:s>
Institute/Functional
<text:s></text:s>
Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Center
<text:s></text:s>
(FFC).
<text:s></text:s>
The
<text:s></text:s>
status
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
FFC’s
<text:s></text:s>
definition
<text:s></text:s>
is
<text:s></text:s>
currently </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>unrecognized
<text:s></text:s>
by
<text:s></text:s>
the
<text:s></text:s>
Food
<text:s></text:s>
and
<text:s></text:s>
Drug
<text:s></text:s>
Administration
<text:s></text:s>
(FDA), </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>but </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recognition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>important </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>safe, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>uniform </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>development and disbursement of functional food products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(FFPs) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>could </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>improve </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Americans </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>people
<text:s></text:s>
around
<text:s></text:s>
the
<text:s></text:s>
world
<text:s></text:s>
struggling
<text:s></text:s>
with
<text:s></text:s>
chronic
<text:s></text:s>
and
<text:s></text:s>
viral </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>diseases.
<text:s></text:s>
If
<text:s></text:s>
functional
<text:s></text:s>
foods
<text:s></text:s>
were
<text:s></text:s>
to
<text:s></text:s>
be
<text:s></text:s>
properly
<text:s></text:s>
termed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>using the FFC’s current definition, they would be classified as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>drug </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>according </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FDA. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Thus, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>communication </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>governmental </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>representatives </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>determine the next steps for functional foods to be properly </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>acknowledged.
<text:s></text:s>
To
<text:s></text:s>
that
<text:s></text:s>
end,
<text:s></text:s>
the
<text:s></text:s>
FFC
<text:s></text:s>
is
<text:s></text:s>
revising
<text:s></text:s>
its
<text:s></text:s>
current </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition
<text:s></text:s>
of
<text:s></text:s>
functional
<text:s></text:s>
foods
<text:s></text:s>
to
<text:s></text:s>
fit
<text:s></text:s>
a
<text:s></text:s>
more
<text:s></text:s>
accurate
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>encompassing idea of the nature of what functional foods do. This includes a shift to stressing how functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
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</draw:polygon>
<draw:polygon>
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</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:polygon>
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</draw:polygon>
<draw:frame>
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<text:span>foods promote optimal health, reduce the risk of chronic/viral disease, and manage their symptoms.
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</text:span>
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<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
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<text:span>FFHD</text:span>
<text:span> </text:span>
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<text:span>Page
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214 of 221 </text:span>
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<text:p>
<text:span>Additionally, the process of developing a functional food product must be standardized to ensure the safety of </text:span>
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<text:p>
<text:span>administering
<text:s></text:s>
bioactive
<text:s></text:s>
compounds
<text:s></text:s>
as
<text:s></text:s>
a
<text:s></text:s>
health
<text:s></text:s>
optimization
<text:s></text:s>
tool.
<text:s></text:s>
This
<text:s></text:s>
process
<text:s></text:s>
follows
<text:s></text:s>
the
<text:s></text:s>
methodology
<text:s></text:s>
of </text:span>
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<text:p>
<text:span>functional food science, which is a potential new form of life science proposed by the Functional Food Center. </text:span>
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<text:p>
<text:span>Over time, the FFC has been developing the appropriate steps to create a functional food product, however, in </text:span>
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<text:p>
<text:span>this article, new steps are emphasized, such as epidemiological studies and after-market research—vital steps to </text:span>
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<text:span>ensuring the safest and most efficacious product is released to the public. Functional foods are not meant to take </text:span>
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<text:span>the place of conventional medicine. They can, however, be used in conjunction with Western medicine and serve </text:span>
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<text:p>
<text:span>as
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an
<text:s></text:s>
aid
<text:s></text:s>
to
<text:s></text:s>
health
<text:s></text:s>
optimization
<text:s></text:s>
for
<text:s></text:s>
people
<text:s></text:s>
with
<text:s></text:s>
chronic/viral
<text:s></text:s>
diseases
<text:s></text:s>
and
<text:s></text:s>
prioritize
<text:s></text:s>
the
<text:s></text:s>
management
<text:s></text:s>
of </text:span>
</text:p>
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<text:span>symptoms associated with those diseases. </text:span>
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<text:span>
<text:s></text:s>
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<text:p>
<text:span>Keywords: </text:span>
<text:span>functional foods, bioactive compounds, biomarkers, functional food science, functional food products, </text:span>
</text:p>
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<text:p></text:p>
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<text:p>
<text:span>epidemiological studies </text:span>
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<text:span>
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</text:span>
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<text:p>
<text:span>©FFC 2021.
<text:s></text:s>
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 </text:span>
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<text:p>
<text:span>License (</text:span>
<text:span>http://creativecommons.org/licenses/by/4.0</text:span>
<text:span>) </text:span>
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<text:span>
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</text:span>
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</text:span>
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<draw:frame>
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<text:p>
<text:span>INTRODUCTION </text:span>
</text:p>
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<text:p>
<text:span>It
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is
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known
<text:s></text:s>
that
<text:s></text:s>
certain
<text:s></text:s>
food
<text:s></text:s>
components
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provide </text:span>
</text:p>
</draw:text-box>
</draw:frame>
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<text:p>
<text:span>health benefits that can potentially aid in disease risk </text:span>
</text:p>
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<text:p>
<text:span>and
<text:s></text:s>
symptom
<text:s></text:s>
management.
<text:s></text:s>
This
<text:s></text:s>
leads
<text:s></text:s>
to
<text:s></text:s>
several </text:span>
</text:p>
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</draw:frame>
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<text:p>
<text:span>food products on the market claiming to have special </text:span>
</text:p>
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</draw:frame>
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<text:p>
<text:span>health benefits which are regulated by the Food and </text:span>
</text:p>
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</draw:frame>
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<text:p>
<text:span>Drug Administration to ensure that foods are safe to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consume
<text:s></text:s>
and
<text:s></text:s>
properly
<text:s></text:s>
labeled
<text:s></text:s>
[1].
<text:s></text:s>
While
<text:s></text:s>
the
<text:s></text:s>
FDA </text:span>
</text:p>
</draw:text-box>
</draw:frame>
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<text:p>
<text:span>does </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>recognize </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>efficacy </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
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<text:p>
<text:span>certain </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds
<text:s></text:s>
having
<text:s></text:s>
disease-related
<text:s></text:s>
health
<text:s></text:s>
benefits, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>they </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>not </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recognized </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>separate </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>category. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>However, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Center is actively seeking to establish a definition for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>these </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>types </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>special </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds, termed “functional foods.”
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Since
<text:s></text:s>
its
<text:s></text:s>
establishment
<text:s></text:s>
in
<text:s></text:s>
1998,
<text:s></text:s>
the
<text:s></text:s>
FFC
<text:s></text:s>
has </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been
<text:s></text:s>
working
<text:s></text:s>
to
<text:s></text:s>
develop
<text:s></text:s>
a
<text:s></text:s>
definition
<text:s></text:s>
for
<text:s></text:s>
functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods
<text:s></text:s>
that
<text:s></text:s>
will
<text:s></text:s>
be
<text:s></text:s>
accepted
<text:s></text:s>
by
<text:s></text:s>
the
<text:s></text:s>
FDA
<text:s></text:s>
to
<text:s></text:s>
create </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>effective FFPs. Currently, Dr. Martirosyan and the FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>define FFs as: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>Natural </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>processed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>contain </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>biologically </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>active </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds; </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>which, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>defined, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>effective </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>non-toxic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>amounts, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>provide </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>clinically </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>proven </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>documented </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefit </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>utilizing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific biomarkers for the prevention, management, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or treatment of chronic/viral disease or its symptoms” </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[2]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The FFC continues to advance this definition as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>more </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds is done and as we learn more about how </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this
<text:s></text:s>
definition
<text:s></text:s>
can
<text:s></text:s>
encompass
<text:s></text:s>
the
<text:s></text:s>
true
<text:s></text:s>
meaning
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>what a functional food does. At the moment, the FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>has proposed a new definition which states: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>Natural </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>processed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>contain </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>biologically-active </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>which, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>defined, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>effective, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>non-toxic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>amounts, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>provide </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>clinically </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>proven </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>documented </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefit </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>utilizing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific biomarkers, to promote optimal health and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>reduce the risk of chronic/viral diseases and manage </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>their symptoms." </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Why
<text:s></text:s>
is
<text:s></text:s>
the
<text:s></text:s>
Definition
<text:s></text:s>
Changing? </text:span>
<text:span>
<text:s></text:s>
As
<text:s></text:s>
we
<text:s></text:s>
learn
<text:s></text:s>
more </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>about
<text:s></text:s>
the
<text:s></text:s>
power
<text:s></text:s>
that
<text:s></text:s>
functional
<text:s></text:s>
foods
<text:s></text:s>
hold,
<text:s></text:s>
it
<text:s></text:s>
is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>important for the Functional Food Center to continue </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>updating the definition to be as reliable and specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as possible to aid in its ability to become official. The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
215 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>former </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specified </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>..utilizing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>biomarkers </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>prevention, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>management, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>treatment </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>chronic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>disease </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>its </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>symptoms.” </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>However,
<text:s></text:s>
the
<text:s></text:s>
most
<text:s></text:s>
recent
<text:s></text:s>
advancement
<text:s></text:s>
reflects
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>shift
<text:s></text:s>
in
<text:s></text:s>
focus
<text:s></text:s>
from
<text:s></text:s>
chronic/viral
<text:s></text:s>
disease
<text:s></text:s>
treatment </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and prevention to </text:span>
<text:span>promotion of optimal health,</text:span>
<text:span> </text:span>
<text:span>risk </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>reduction, and management of symptoms. </text:span>
<text:span>With this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>change, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>clarifies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>they </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>understand </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>will </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>never </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>replace </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>conventional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>medicine in terms of disease treatment. Rather, there </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>will always be an intersection of the two in order to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>generate the best outcomes for diseased individuals' </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Moreover, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>promotes </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>possibility of involvement from the food industry in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research and development.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Another aspect of the definition modification is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that
<text:s></text:s>
currently,
<text:s></text:s>
the
<text:s></text:s>
FDA
<text:s></text:s>
reserves
<text:s></text:s>
the
<text:s></text:s>
terminology
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>treatment
<text:s></text:s>
and
<text:s></text:s>
prevention”
<text:s></text:s>
for
<text:s></text:s>
the
<text:s></text:s>
description
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>drugs. Personal communication between the FFC and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FDA </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>says </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>even </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>if </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>certain </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>contain </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds proven to treat disease, a FFP containing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>those compounds will be viewed as a drug, not a food. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Creating a standardized definition of functional foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>means </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>product </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>development </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>would become more effective and ultimately end up </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>having a larger impact on chronic and viral diseases </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>worldwide. Functional food developments could start </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>being </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>used </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>management </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>symptoms </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>associated with chronic and viral diseases and would </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ideally
<text:s></text:s>
not
<text:s></text:s>
be
<text:s></text:s>
viewed
<text:s></text:s>
as
<text:s></text:s>
a
<text:s></text:s>
drug,
<text:s></text:s>
or
<text:s></text:s>
medicine,
<text:s></text:s>
but </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>rather </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>By </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>agreeing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>standardized </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>establishing functional food science as a distinct field </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>life </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>sciences, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>can </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>be </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>created
<text:s></text:s>
and
<text:s></text:s>
trusted
<text:s></text:s>
by
<text:s></text:s>
the
<text:s></text:s>
public.
<text:s></text:s>
This
<text:s></text:s>
creates
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>whole
<text:s></text:s>
new
<text:s></text:s>
category
<text:s></text:s>
of
<text:s></text:s>
symptom
<text:s></text:s>
management
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>risk reduction for chronic and viral diseases.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>What Is the Goal</text:span>
<text:span>: Functional food science is focused </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on the rigorous, systematic research and production </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of functional food products [3]. The goal of updating </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the definition of functional foods is to create a clearer </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>understanding of how a functional food product must </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>be developed, evaluated, and used for general health, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>risk </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>reduction </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>chronic/viral </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>disease, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>management of their symptoms. If this goal is
<text:s></text:s>
met, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>there
<text:s></text:s>
is
<text:s></text:s>
a
<text:s></text:s>
greater
<text:s></text:s>
chance
<text:s></text:s>
that
<text:s></text:s>
food
<text:s></text:s>
will
<text:s></text:s>
become
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>common
<text:s></text:s>
part
<text:s></text:s>
of
<text:s></text:s>
frontline,
<text:s></text:s>
preventative
<text:s></text:s>
medicine. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Science shows that there are foods with documented </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health benefits that are effective at reducing disease </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>risk and managing symptoms. For example, fruits and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vegetables are associated with a lower risk of cancer, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>coronary
<text:s></text:s>
heart
<text:s></text:s>
disease,
<text:s></text:s>
and
<text:s></text:s>
stroke,
<text:s></text:s>
and
<text:s></text:s>
coffee
<text:s></text:s>
has </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been associated with a lower risk of developing type </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>diabetes </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[4]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>There </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>will </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>always </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>be </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>need </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>medication in disease treatment, but the idea behind </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC’s </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFs </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>we </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>will </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>legitimate means, aside from only Western medicine, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to manage the symptoms of diseases.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>How
<text:s></text:s>
to
<text:s></text:s>
Accomplish
<text:s></text:s>
the
<text:s></text:s>
Goal</text:span>
<text:span>: </text:span>
<text:span>
<text:s></text:s>
After
<text:s></text:s>
having
<text:s></text:s>
spoken </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with governmental agencies and representatives, it is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>clear that they all feel that functional foods would be </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>classified </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>drug </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>current </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>proposed. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>So, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>further </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>efforts </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recognized
<text:s></text:s>
definition
<text:s></text:s>
of
<text:s></text:s>
functional
<text:s></text:s>
foods,
<text:s></text:s>
the
<text:s></text:s>
FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>continues </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>speak </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>governmental </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>agencies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>about what can be done to improve our system for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional
<text:s></text:s>
foods
<text:s></text:s>
and
<text:s></text:s>
how
<text:s></text:s>
we
<text:s></text:s>
can
<text:s></text:s>
continue
<text:s></text:s>
working </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with functional foods to get them acknowledged. In </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>addition, a unified definition allows for a step-by-step </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>process to be developed in which potential functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>researched, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>strict </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>trials </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>presented </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>showing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>efficacy </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>safety, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products are officially established to be marketed to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the public.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
216 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Steps </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Developing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(FFPs): </text:span>
<text:span>In addition to defining functional foods, it is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>also very important to define functional food science. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>science </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>clarifies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>definition </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional foods, the development of new functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds for specific health improvement, and the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>risk reduction of chronic and viral diseases. This will </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>give a groundwork for not only being able to identify </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>what
<text:s></text:s>
functional
<text:s></text:s>
foods
<text:s></text:s>
are,
<text:s></text:s>
but
<text:s></text:s>
will
<text:s></text:s>
also
<text:s></text:s>
include
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>guide for how to study, develop, and market a FFP. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional food science encompasses the process of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>developing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>product </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>through </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>rigorous, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>systematic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>determine </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>extra-nutritive components of the food that promote </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>positive effects on health [3].</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Product </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>development </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>long </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>process </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>but </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ideally, one that, if it begins gaining recognition, can </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>serve
<text:s></text:s>
as
<text:s></text:s>
a
<text:s></text:s>
guide
<text:s></text:s>
for
<text:s></text:s>
functional
<text:s></text:s>
food
<text:s></text:s>
scientists
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>researchers
<text:s></text:s>
all
<text:s></text:s>
around
<text:s></text:s>
the
<text:s></text:s>
world
<text:s></text:s>
to
<text:s></text:s>
develop
<text:s></text:s>
their </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional food products. Dr. Martirosyan and the FFC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>outline </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>procedural
<text:s></text:s>
steps </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>achieve </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>goal </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(Figure 1): </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>1.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Establish
<text:s></text:s>
the
<text:s></text:s>
goal
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
FFP.
<text:s></text:s>
Specifically, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>explore
<text:s></text:s>
the
<text:s></text:s>
data
<text:s></text:s>
of
<text:s></text:s>
recent
<text:s></text:s>
or
<text:s></text:s>
past
<text:s></text:s>
studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>using </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>history, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ethnobotany,
<text:s></text:s>
anthropology, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>archeology, and other fields that may give us </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>insight into potential applications of FFs. The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>goal needs to be specific, such as alleviating </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>certain
<text:s></text:s>
symptoms
<text:s></text:s>
or
<text:s></text:s>
restoring
<text:s></text:s>
balance
<text:s></text:s>
to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>diseased
<text:s></text:s>
or
<text:s></text:s>
imbalanced
<text:s></text:s>
areas
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
mind, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>brain, and body.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>After
<text:s></text:s>
establishing
<text:s></text:s>
a
<text:s></text:s>
specific
<text:s></text:s>
goal,
<text:s></text:s>
conduct </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>literature reviews to determine the relevant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioactive compound(s) (BC) that effectuates </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the goal. Concerning FFs, the FFC states that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>BCs </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>...or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>secondary </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>metabolites </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>molecules in food, usually in small amounts, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that act synergistically to benefit health” [5]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>3.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Establish
<text:s></text:s>
the
<text:s></text:s>
appropriate
<text:s></text:s>
dosage
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
BC </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>needed for the desired goal of the FFP. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>4.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Determine </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>molecular </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>mechanism
<text:s></text:s>
or
<text:s></text:s>
biological
<text:s></text:s>
pathway
<text:s></text:s>
that
<text:s></text:s>
the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>BC exerts on the body or brain. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>5.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Discover
<text:s></text:s>
the
<text:s></text:s>
relevant
<text:s></text:s>
biomarker(s)
<text:s></text:s>
related </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to the mechanism and pathway. This step is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vital in providing scientific evidence for the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>efficacy of the FFP. The biomarkers provide </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ability </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>measurable </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>quantifiable variable that can be tested.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>6.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Create </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>choose </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vehicle </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>best </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>appropriate for the administration of the BC. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>A food vehicle is a food in its natural state, or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a food product developed to deliver BCs to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the consumer.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>7.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Perform or provide preclinical in vitro and in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vivo studies using animals to determine safe </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and efficacious dosages of the BC.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>8.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Perform
<text:s></text:s>
or
<text:s></text:s>
provide
<text:s></text:s>
clinical
<text:s></text:s>
human
<text:s></text:s>
trials
<text:s></text:s>
to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>refine
<text:s></text:s>
the
<text:s></text:s>
dosage
<text:s></text:s>
appropriate
<text:s></text:s>
for
<text:s></text:s>
humans </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>utilizing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>relevant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>biomarker(s). </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>These </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>trials must be done with strict compliance to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>determine safety and efficacy. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>9.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Create </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>special </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>label </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFP </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>sufficiently
<text:s></text:s>
informs
<text:s></text:s>
consumers
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
most </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>effective way to consume the product. This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>includes </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consumption </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>instructions </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>dosage </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recommendations, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>well </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>shelf
<text:s></text:s>
life
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
BC(s)
<text:s></text:s>
to
<text:s></text:s>
ensure
<text:s></text:s>
effective </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioavailability.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>10.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Marketing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFP </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>must </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>be </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>done </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>educate
<text:s></text:s>
the
<text:s></text:s>
public
<text:s></text:s>
on
<text:s></text:s>
the
<text:s></text:s>
potential
<text:s></text:s>
health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefits
<text:s></text:s>
and
<text:s></text:s>
biomarkers
<text:s></text:s>
that
<text:s></text:s>
can
<text:s></text:s>
be
<text:s></text:s>
seen </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and felt from proper usage and to persuade </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>its use of the original goals of the FFP.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>11.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>After </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>marketing, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>need to be conducted to determine the FFP’s </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>efficacy, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>dosage, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>safety </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>an </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
217 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>uncontrolled,
<text:s></text:s>
non-laboratory
<text:s></text:s>
environment. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>This step is crucial and will help build trust </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for the public. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>12.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Data and information on the epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies
<text:s></text:s>
must
<text:s></text:s>
be sent
<text:s></text:s>
to trusted
<text:s></text:s>
third-party </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>organizations and government
<text:s></text:s>
agencies for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>approval to market.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>13.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Release the FFP to the market. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>14.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Continue
<text:s></text:s>
to
<text:s></text:s>
perform
<text:s></text:s>
aftermarket
<text:s></text:s>
research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to
<text:s></text:s>
monitor
<text:s></text:s>
the
<text:s></text:s>
potential
<text:s></text:s>
gap
<text:s></text:s>
between
<text:s></text:s>
the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>controlled studies and how the FFP actually </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>affects
<text:s></text:s>
an
<text:s></text:s>
individual’s
<text:s></text:s>
health
<text:s></text:s>
and
<text:s></text:s>
relevant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>biomarker(s). </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>important </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>last </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>working </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>step ensures the product will be refined to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>maximize efficacy, increase safety, and help </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>future
<text:s></text:s>
products
<text:s></text:s>
potentially
<text:s></text:s>
using
<text:s></text:s>
the
<text:s></text:s>
same </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or similar BC(s) and biomarkers. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>15.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Official establishment of the FFP. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Figure 1</text:span>
<text:span>. Steps to develop functional food products and bring them to the market</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Examples of Various Steps </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Establishing the Goal of the FFP</text:span>
<text:span>: As mentioned, there </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>many </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fields </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>at </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>our </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>disposal </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>discovering </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>potential functional foods. Ethnobotany, for instance, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>researches
<text:s></text:s>
the
<text:s></text:s>
historic,
<text:s></text:s>
traditional
<text:s></text:s>
use
<text:s></text:s>
of
<text:s></text:s>
plants
<text:s></text:s>
as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>medicine in primitive or non-western cultures. While </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Ethnopharmacology </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>focuses </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioactivity </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>traditional
<text:s></text:s>
remedies
<text:s></text:s>
[6].
<text:s></text:s>
One
<text:s></text:s>
example
<text:s></text:s>
of
<text:s></text:s>
this
<text:s></text:s>
use </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>comes </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>from </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Black </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>elderberry </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(Sambucus
<text:s></text:s>
nigra),
<text:s></text:s>
which
<text:s></text:s>
has been
<text:s></text:s>
demonstrated
<text:s></text:s>
to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>manage
<text:s></text:s>
the
<text:s></text:s>
symptoms
<text:s></text:s>
of
<text:s></text:s>
influenza
<text:s></text:s>
and
<text:s></text:s>
other
<text:s></text:s>
viral </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>respiratory diseases/illnesses [7]. Researching within </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>these two fields can be a great start to establishing a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific goal of a potential FFP.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Find </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Relevant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Compounds</text:span>
<text:span>:</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>BCs </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>occurring </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>most </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fruits </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vegetables </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>include </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>phytochemicals
<text:s></text:s>
such
<text:s></text:s>
as
<text:s></text:s>
phenolics
<text:s></text:s>
and
<text:s></text:s>
carotenoids, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and bananas, for example, contain high amounts of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:image>
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<text:span>these compounds. Specific phenolic compounds like </text:span>
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<draw:page>
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<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
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<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
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<text:p></text:p>
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<text:span>Page
<text:s></text:s>
218 of 221 </text:span>
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<text:s></text:s>
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<draw:frame>
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<text:span>gallic </text:span>
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<draw:frame>
<draw:text-box>
<text:p>
<text:span>acid, </text:span>
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<draw:frame>
<draw:text-box>
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<text:span>catechin, </text:span>
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<draw:frame>
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<text:span>epicatechin, </text:span>
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<text:span>tannins, </text:span>
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<text:span>and </text:span>
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<text:span>anthocyanins </text:span>
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<draw:frame>
<draw:text-box>
<text:p>
<text:span>are </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>most </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>abundant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fruit. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Furthermore,
<text:s></text:s>
bananas
<text:s></text:s>
contain
<text:s></text:s>
flavonoids,
<text:s></text:s>
biogenic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>amines,
<text:s></text:s>
and
<text:s></text:s>
even
<text:s></text:s>
small
<text:s></text:s>
amounts
<text:s></text:s>
of
<text:s></text:s>
phytosterols. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Thus,
<text:s></text:s>
making
<text:s></text:s>
bananas
<text:s></text:s>
one
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
most
<text:s></text:s>
powerful </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>antioxidant fruits [8]. </text:span>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Determine </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Molecular </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Mechanism </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Biological
<text:s></text:s>
Pathway</text:span>
<text:span>:
<text:s></text:s>
The
<text:s></text:s>
BCs
<text:s></text:s>
previously
<text:s></text:s>
mentioned </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with
<text:s></text:s>
bananas,
<text:s></text:s>
provide
<text:s></text:s>
an
<text:s></text:s>
antioxidant
<text:s></text:s>
effect
<text:s></text:s>
on
<text:s></text:s>
the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>body. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>specific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>mechanism </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>these </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds work to delay or prevent the oxidation or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>free radical formation of cells [8].</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Find </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Relative </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Biomarker(s)</text:span>
<text:span>: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>An </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>example </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>measurable
<text:s></text:s>
biomarkers
<text:s></text:s>
can
<text:s></text:s>
be
<text:s></text:s>
seen
<text:s></text:s>
in
<text:s></text:s>
the
<text:s></text:s>
health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefits of the cacao bean. “Cacao (or cocoa) beans </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are technically not beans or legumes, but rather the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>seeds of the fruit of the Theobroma cacao tree” [9]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>super-fruit” </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>has </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>shown </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>lower </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cholesterol
<text:s></text:s>
levels,
<text:s></text:s>
reduce
<text:s></text:s>
resistance
<text:s></text:s>
to
<text:s></text:s>
insulin,
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>improve </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>insulin </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>sensitivity </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>healthy, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>obese, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>insulin-resistant individuals[10].</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Choose/Develop </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Appropriate </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Vehicle</text:span>
<text:span>:</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Sometimes </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>when </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>choosing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vehicle </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>administer
<text:s></text:s>
the
<text:s></text:s>
BCs,
<text:s></text:s>
researchers
<text:s></text:s>
and
<text:s></text:s>
scientists
<text:s></text:s>
alter </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>existing products, such as adding or enriching them </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>vitamins, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>minerals, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>other </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>There
<text:s></text:s>
are
<text:s></text:s>
a
<text:s></text:s>
few
<text:s></text:s>
different
<text:s></text:s>
reasons
<text:s></text:s>
for
<text:s></text:s>
this,
<text:s></text:s>
such
<text:s></text:s>
as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>making
<text:s></text:s>
the
<text:s></text:s>
product
<text:s></text:s>
more
<text:s></text:s>
nutritious,
<text:s></text:s>
making
<text:s></text:s>
them </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>more </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>desirable </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consumers, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>even </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>environmental and economic benefits. One study, for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>example,
<text:s></text:s>
conducted
<text:s></text:s>
how
<text:s></text:s>
adding
<text:s></text:s>
pumpkin
<text:s></text:s>
pulp
<text:s></text:s>
to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>wheat
<text:s></text:s>
bread
<text:s></text:s>
could
<text:s></text:s>
bring
<text:s></text:s>
about
<text:s></text:s>
these
<text:s></text:s>
benefits.
<text:s></text:s>
The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>pulp </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>provided </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bread </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>...potentially </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioaccessible </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>phenolics </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(including </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>flavonoids) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>especially, with peptides” [11]. Furthermore, the pulp </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>“</text:span>
<text:span>...significantly
<text:s></text:s>
enriched
<text:s></text:s>
the
<text:s></text:s>
bread
<text:s></text:s>
with
<text:s></text:s>
potentially </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bioaccessible
<text:s></text:s>
angiotensin-converting
<text:s></text:s>
enzyme
<text:s></text:s>
(ACE) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>inhibitors” </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[11]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Not </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>only </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>did </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>increase </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>nutritive component of the food product, but it also </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>made
<text:s></text:s>
it
<text:s></text:s>
more
<text:s></text:s>
palatable
<text:s></text:s>
and
<text:s></text:s>
reduced
<text:s></text:s>
the
<text:s></text:s>
cost
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>production. Often, pumpkin pulp is simply disposed of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>after acquiring the seeds and the flesh of the fruit. So, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this process provides environmental benefits as well </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[11].</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Preclinical Trials</text:span>
<text:span>:</text:span>
<text:span> </text:span>
<text:span>One example comes from Seeram </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and colleagues who tested the effects of six different </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>berry extracts (blackberry, black raspberry, blueberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cranberry,
<text:s></text:s>
red
<text:s></text:s>
raspberry,
<text:s></text:s>
and
<text:s></text:s>
strawberry)
<text:s></text:s>
and
<text:s></text:s>
their </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ability
<text:s></text:s>
to
<text:s></text:s>
inhibit
<text:s></text:s>
the
<text:s></text:s>
growth
<text:s></text:s>
of
<text:s></text:s>
human
<text:s></text:s>
oral,
<text:s></text:s>
breast, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>colon, and prostate tumor cells and induce apoptosis </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in vitro [12]. This study gives credence to furthering </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the research in vivo with animals to test for the same </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>positive effects.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Clinical </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Trials</text:span>
<text:span>:</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Chen </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>colleagues </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(2012) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>demonstrate a proper human clinical trial with their </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>how </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>freeze-dried </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>strawberry </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>powder </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>significantly reduced the risk of esophageal cancer in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a
<text:s></text:s>
high-risk
<text:s></text:s>
population
<text:s></text:s>
[13].
<text:s></text:s>
In
<text:s></text:s>
this
<text:s></text:s>
clinical
<text:s></text:s>
trial,
<text:s></text:s>
the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>researchers were able to adjust and find the proper </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>human dosage to have the desired effects.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Create Special Functional Food Label</text:span>
<text:span>:</text:span>
<text:span> </text:span>
<text:span>Currently, the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FDA authorizes statements (health claims) made on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food or food components that indicate a relationship </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>between </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>an </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>active </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>ingredient, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compound
<text:s></text:s>
and
<text:s></text:s>
a
<text:s></text:s>
specific
<text:s></text:s>
disease
<text:s></text:s>
[14].
<text:s></text:s>
This
<text:s></text:s>
process </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>requires
<text:s></text:s>
significant
<text:s></text:s>
agreement
<text:s></text:s>
among
<text:s></text:s>
the
<text:s></text:s>
scientific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>community
<text:s></text:s>
and
<text:s></text:s>
a
<text:s></text:s>
series
<text:s></text:s>
of
<text:s></text:s>
evidence
<text:s></text:s>
in
<text:s></text:s>
clinical
<text:s></text:s>
or </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>observational studies to show a true relationship. The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC
<text:s></text:s>
emphasizes,
<text:s></text:s>
however,
<text:s></text:s>
the
<text:s></text:s>
importance
<text:s></text:s>
and
<text:s></text:s>
the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>need for the bioactive compound on the label. This is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fundamental
<text:s></text:s>
in
<text:s></text:s>
the
<text:s></text:s>
entire
<text:s></text:s>
process
<text:s></text:s>
of
<text:s></text:s>
establishing
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional food product.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
219 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Market
<text:s></text:s>
Functional
<text:s></text:s>
Food
<text:s></text:s>
Product</text:span>
<text:span>:</text:span>
<text:span> </text:span>
<text:span>
<text:s></text:s>
Marketing
<text:s></text:s>
is
<text:s></text:s>
an </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>important step and one that may be carried out by a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>separate </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>marketing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>team. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Just </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>imperative in the preclinical and clinical trial, it is also </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>so
<text:s></text:s>
for
<text:s></text:s>
the
<text:s></text:s>
marketing
<text:s></text:s>
process.
<text:s></text:s>
There
<text:s></text:s>
needs
<text:s></text:s>
to
<text:s></text:s>
be
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>balanced struck between educating the public of the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>potential
<text:s></text:s>
health
<text:s></text:s>
benefits,
<text:s></text:s>
as
<text:s></text:s>
well
<text:s></text:s>
as
<text:s></text:s>
showcasing
<text:s></text:s>
a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>product worth purchasing by a variety of populations. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Huang
<text:s></text:s>
and
<text:s></text:s>
colleagues
<text:s></text:s>
conducted
<text:s></text:s>
a
<text:s></text:s>
study
<text:s></text:s>
to
<text:s></text:s>
better </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>understand consumer behavior with functional foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in China. They found that “Trust in the food system </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and health consciousness positively affects purchase </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>intention
<text:s></text:s>
via
<text:s></text:s>
purchase
<text:s></text:s>
attitude”
<text:s></text:s>
[15].
<text:s></text:s>
Furthermore, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>while price can negatively affect purchase intention, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>it can be offset by health consciousness. [15]. Another </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>study </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>from </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Nilova </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Malyutenkova </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>sought </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>develop
<text:s></text:s>
an
<text:s></text:s>
algorithm
<text:s></text:s>
for
<text:s></text:s>
assessing
<text:s></text:s>
the
<text:s></text:s>
competitive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>abilities of functional foods in marketing, specifically </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bread </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bakery </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consisted </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>combination between the “Harrington method” and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the
<text:s></text:s>
“Triangle
<text:s></text:s>
of
<text:s></text:s>
desirability
<text:s></text:s>
of
<text:s></text:s>
consumer
<text:s></text:s>
features" </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[16]. The former addresses the competitive factors of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFs to be functionality, quality, shelf life, technology, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>social importance, price, safety, and consumer, while </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the latter represents safety, quality, and functionality </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[16]. </text:span>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Pilot/Epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Studies</text:span>
<text:span>:</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies
<text:s></text:s>
are
<text:s></text:s>
vitally
<text:s></text:s>
important
<text:s></text:s>
for
<text:s></text:s>
developing
<text:s></text:s>
trusted </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional
<text:s></text:s>
food
<text:s></text:s>
products.
<text:s></text:s>
For
<text:s></text:s>
example,
<text:s></text:s>
olive
<text:s></text:s>
oil
<text:s></text:s>
has </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>regarded </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>healthy </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fat </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cooking </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>oil, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consumed largely
<text:s></text:s>
in the
<text:s></text:s>
Mediterranean diet
<text:s></text:s>
[17].
<text:s></text:s>
A </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>large </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>review </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>article </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>investigated </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>numerous </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>surrounding </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefits of olive oil consumption. This review paints a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>more accurate picture of the true health benefits of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>olive
<text:s></text:s>
oil
<text:s></text:s>
in
<text:s></text:s>
a
<text:s></text:s>
real-world,
<text:s></text:s>
uncontrolled
<text:s></text:s>
environment, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>such
<text:s></text:s>
as
<text:s></text:s>
strengthening
<text:s></text:s>
the
<text:s></text:s>
claims
<text:s></text:s>
that
<text:s></text:s>
it
<text:s></text:s>
has
<text:s></text:s>
cardio-</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>protective benefits [17].</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Release to Market and After Market Research</text:span>
<text:span>: </text:span>
<text:span>The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>final </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>two </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>steps </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>developing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>a </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>product
<text:s></text:s>
include
<text:s></text:s>
release
<text:s></text:s>
to
<text:s></text:s>
market
<text:s></text:s>
and
<text:s></text:s>
aftermarket </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research.
<text:s></text:s>
To
<text:s></text:s>
gain
<text:s></text:s>
the
<text:s></text:s>
most
<text:s></text:s>
desirable
<text:s></text:s>
results
<text:s></text:s>
from </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>post-market
<text:s></text:s>
research,
<text:s></text:s>
it
<text:s></text:s>
is
<text:s></text:s>
important
<text:s></text:s>
to
<text:s></text:s>
continue </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>marketing even once the product has been released. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>higher </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>consumption </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>rates, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>more </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>significant </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>aftermarket </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>results </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>are. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>These </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>kinds </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>allow </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>continued </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>modification
<text:s></text:s>
of
<text:s></text:s>
the
<text:s></text:s>
functional
<text:s></text:s>
food
<text:s></text:s>
product
<text:s></text:s>
to
<text:s></text:s>
best </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>meet consumer’s health needs.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Limitations </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>After </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Market </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Epidemiological
<text:s></text:s>
Studies: </text:span>
<text:span>
<text:s></text:s>
After-market
<text:s></text:s>
research
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological studies are very time-consuming and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>costly. Therefore, they can create significant hurdles </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to the establishment of a FFP. Dr. Martirosyan and the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC recommend that distinct categories are created </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>so that products can be labeled before these studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and research. This can be represented on the label to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>inform consumers that long-term studies have not yet </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>been
<text:s></text:s>
presented
<text:s></text:s>
but
<text:s></text:s>
ideally
<text:s></text:s>
will
<text:s></text:s>
in
<text:s></text:s>
the
<text:s></text:s>
future.
<text:s></text:s>
This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>would
<text:s></text:s>
help
<text:s></text:s>
products
<text:s></text:s>
to
<text:s></text:s>
be
<text:s></text:s>
marketed
<text:s></text:s>
in
<text:s></text:s>
a
<text:s></text:s>
relatively </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cost-effective and timely manner. Of course, products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that have after-market research and epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies to back them up would have that categorical </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>distinction. </text:span>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>CONCLUSION </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The FDA currently acknowledges certain health claims </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>some </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>demonstrated </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefits </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>humans </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[1,14]. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>They </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>have, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>however, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>failed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recognize </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>category </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional foods as a legitimate category in the food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>industry. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Based </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>reviewed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>article, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>many </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>different </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>hold </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>potential to reduce the risk of disease and, therefore, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>could be labeled as official FFPs. The Functional Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Center
<text:s></text:s>
has
<text:s></text:s>
been
<text:s></text:s>
providing
<text:s></text:s>
updated
<text:s></text:s>
definitions
<text:s></text:s>
for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
220 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional foods and requests that the FDA works to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>accept a unified definition that encompasses the true </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>power
<text:s></text:s>
of
<text:s></text:s>
functional
<text:s></text:s>
foods
<text:s></text:s>
in
<text:s></text:s>
disease
<text:s></text:s>
risk
<text:s></text:s>
reduction </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>management </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>its </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>associated </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>symptoms. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional
<text:s></text:s>
foods
<text:s></text:s>
can
<text:s></text:s>
be
<text:s></text:s>
a
<text:s></text:s>
distinct
<text:s></text:s>
category
<text:s></text:s>
used
<text:s></text:s>
in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>conjunction with current Western medical practices </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to help deal with the epidemic of chronic/viral disease </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>plaguing America and most of the developed world. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The FFC has also outlined steps that can be used </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>research </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>create </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFPs </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>public. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>This </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>systematic, rigorous research is known as functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food science and the FFC hopes for it to be recognized </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>as a distinct form of life sciences. Lastly, and perhaps </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>most </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>important, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>is </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>need </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies
<text:s></text:s>
and
<text:s></text:s>
continuous
<text:s></text:s>
after-market
<text:s></text:s>
research
<text:s></text:s>
that </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>follows
<text:s></text:s>
up
<text:s></text:s>
to
<text:s></text:s>
find
<text:s></text:s>
any
<text:s></text:s>
gaps
<text:s></text:s>
in
<text:s></text:s>
research
<text:s></text:s>
between </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>controlled studies and an uncontrolled environment </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>where
<text:s></text:s>
the
<text:s></text:s>
products
<text:s></text:s>
are
<text:s></text:s>
used
<text:s></text:s>
by
<text:s></text:s>
consumers.
<text:s></text:s>
These </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>new steps included in the process of developing a FFP </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cannot
<text:s></text:s>
be
<text:s></text:s>
stressed
<text:s></text:s>
enough
<text:s></text:s>
because
<text:s></text:s>
they
<text:s></text:s>
allow
<text:s></text:s>
for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products to be refined to increase efficacy and safety. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The FFC is also aware of the limitations and hurdles </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>created by these steps in creating FFPs. So, to address </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>this issue, the FFC is working on developing potential </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>distinct </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>categories </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>without </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological studies and aftermarket research.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Abbreviations: </text:span>
<text:span>FFs: Functional foods, FFC: Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food
<text:s></text:s>
Center,
<text:s></text:s>
FDA:
<text:s></text:s>
Food
<text:s></text:s>
and
<text:s></text:s>
Drug
<text:s></text:s>
Administration, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFP/FFPs,
<text:s></text:s>
Functional
<text:s></text:s>
food
<text:s></text:s>
product/Functional
<text:s></text:s>
food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>BC/BCs: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compound/Bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds, ACE: Angiotensin-converting enzyme</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Authors’ </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Contributions</text:span>
<text:span>: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Danik </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Martirosyan, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>PhD: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>conceived
<text:s></text:s>
and
<text:s></text:s>
designed
<text:s></text:s>
the
<text:s></text:s>
study,
<text:s></text:s>
analyzed,
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>interpreted the data, and actively involved in writing </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and editing the manuscript; Hunter Kanya, and Camila </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Nadalet (intern students at FFC): collected the data, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>wrote the manuscript.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Conflict of Interest: </text:span>
<text:span>The authors declare no conflict of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>interest.</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Acknowledgments: </text:span>
<text:span>No external funding was needed </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>or given for this review article</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>REFERENCES</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>1.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Guidance </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Industry: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Labeling </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Guide </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[https://www.fda.gov/regulatory-information/search-</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>fda-guidance-documents/guidance-industry-food-</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>labeling-guide] Retrieved March 5, 2021. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Leem
<text:s></text:s>
C,
<text:s></text:s>
Martirosyan
<text:s></text:s>
D:
<text:s></text:s>
The
<text:s></text:s>
bioactive
<text:s></text:s>
compounds
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>probiotic
<text:s></text:s>
foods/supplements
<text:s></text:s>
and
<text:s></text:s>
their
<text:s></text:s>
application
<text:s></text:s>
in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>managing
<text:s></text:s>
mental
<text:s></text:s>
disorders. </text:span>
<text:span>
<text:s></text:s>
Bioactive
<text:s></text:s>
Compounds
<text:s></text:s>
in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Health and Disease</text:span>
<text:span> 2019, 2(10): 206-220 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>3.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Liufu </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>J, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Martirosyan </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>D: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFC’s </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>advancement </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>establishment
<text:s></text:s>
of
<text:s></text:s>
functional
<text:s></text:s>
food
<text:s></text:s>
science. </text:span>
<text:span>
<text:s></text:s>
Functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food in Health and Disease</text:span>
<text:span> 2020; 10(8):344-356. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>4.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Schulze </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>MB, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Martinez-Gonzalez </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>MA, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Fung </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>TT, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Lichtenstein
<text:s></text:s>
AH,
<text:s></text:s>
and
<text:s></text:s>
Forouhi
<text:s></text:s>
NG:
<text:s></text:s>
Food
<text:s></text:s>
based
<text:s></text:s>
dietary </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>patterns
<text:s></text:s>
and
<text:s></text:s>
chronic
<text:s></text:s>
disease
<text:s></text:s>
prevention. </text:span>
<text:span>
<text:s></text:s>
BMJ </text:span>
<text:span>
<text:s></text:s>
2018,</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>361</text:span>
<text:span>(8157). </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>5.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Martirosyan D, Singh, J: A new definition of functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>food
<text:s></text:s>
by
<text:s></text:s>
FFC:
<text:s></text:s>
what
<text:s></text:s>
makes
<text:s></text:s>
a
<text:s></text:s>
new
<text:s></text:s>
definition
<text:s></text:s>
unique? </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease </text:span>
<text:span>2015,</text:span>
<text:span> 5</text:span>
<text:span>(6):209-</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>223. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>6.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Vandebroek
<text:s></text:s>
I:
<text:s></text:s>
Intercultural
<text:s></text:s>
health
<text:s></text:s>
and
<text:s></text:s>
ethnobotany: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>How </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>improve </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>healthcare </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>underserved </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>minority
<text:s></text:s>
communities? </text:span>
<text:span>
<text:s></text:s>
Journal
<text:s></text:s>
of
<text:s></text:s>
Ethnopharmacology</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2013, 148(3): 746-754. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>7.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Macknin M, Wolski K, Negrey J, and Mace S: Elderberry </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>extract
<text:s></text:s>
outpatient
<text:s></text:s>
influenza
<text:s></text:s>
treatment
<text:s></text:s>
for
<text:s></text:s>
emergency </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>room patients ages 5 and above: A randomized, double-</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>blind, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>placebo-controlled </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>trial. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Journal </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>General </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Internal Medicine</text:span>
<text:span> 2020, 35:3271–3277. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>8.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Singh </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>B, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Singh </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>JP, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Kaur </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>A, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Singh </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>N: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Bioactive </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>compounds </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>banana </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>their </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>associated </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>benefits–A review. </text:span>
<text:span>Food Chemistry 2016, 206:</text:span>
<text:span>1-11.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>9.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Crozier
<text:s></text:s>
SJ,
<text:s></text:s>
Preston
<text:s></text:s>
AG,
<text:s></text:s>
Hurst
<text:s></text:s>
JW,
<text:s></text:s>
Payne
<text:s></text:s>
MJ,
<text:s></text:s>
Mann
<text:s></text:s>
J, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Hainly L, and Miller DL: Cacao seeds are a “Super Fruit”: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>A
<text:s></text:s>
comparative
<text:s></text:s>
analysis
<text:s></text:s>
of
<text:s></text:s>
various
<text:s></text:s>
fruit
<text:s></text:s>
powders
<text:s></text:s>
and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>products. </text:span>
<text:span>Chemistry Central Journal</text:span>
<text:span> 2011, 5(5):1–6. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
<draw:page>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Functional Foods in Health and Disease</text:span>
<text:span> 2021; 11(5): 213-221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>FFHD</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:polygon>
<text:p></text:p>
</draw:polygon>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Page
<text:s></text:s>
221 of 221 </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>10.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Araujo
<text:s></text:s>
Q
<text:s></text:s>
R,
<text:s></text:s>
Gattward
<text:s></text:s>
JN,
<text:s></text:s>
Almoosawi
<text:s></text:s>
S,
<text:s></text:s>
Parada
<text:s></text:s>
Costa </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Silva MGC, Santana D, Quintino PA, Araujo Jr R: Cocoa </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>human </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>From </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>head </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>to </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foot—A </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>review. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Critical
<text:s></text:s>
Reviews
<text:s></text:s>
in
<text:s></text:s>
Food
<text:s></text:s>
Science
<text:s></text:s>
and
<text:s></text:s>
Nutrition </text:span>
<text:span>
<text:s></text:s>
2016, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>56(1):1-12.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>11.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Różyło ., Gawlik-Dziki U, Dziki D, Jakubczyk A, Karaś M, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Różyło </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>K: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Wheat </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>bread </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>pumpkin </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>(Cucurbita </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>maxima
<text:s></text:s>
L.)
<text:s></text:s>
pulp
<text:s></text:s>
as
<text:s></text:s>
a
<text:s></text:s>
functional
<text:s></text:s>
food
<text:s></text:s>
product. </text:span>
<text:span>
<text:s></text:s>
Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Technology and Biotechnology</text:span>
<text:span> 2014, 52(4):430–438. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>12.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>HS, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>et </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>al: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Blackberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>black </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>raspberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>blueberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cranberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>red </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>raspberry, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>strawberry </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>extracts </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>inhibit growth and stimulate apoptosis of human cancer </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cells in vitro. </text:span>
<text:span>Journal of Agricultural and Food Chemistry</text:span>
<text:span> </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2006, 54(25):9329–9339. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>13.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Chen T, Yan F, Qian J, Guo M, Zhang H, Tang X, Chen F, </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Stoner
<text:s></text:s>
GD,
<text:s></text:s>
and
<text:s></text:s>
Wang
<text:s></text:s>
X:
<text:s></text:s>
Randomized
<text:s></text:s>
phase
<text:s></text:s>
II
<text:s></text:s>
trial
<text:s></text:s>
of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>lyophilized </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>strawberries </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>patients </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>with </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>dysplastic </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>precancerous </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>lesions </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>esophagus. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Cancer </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Prevention Research Phila</text:span>
<text:span> 2012, 5:41–50. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>14.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>U.S. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Food </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Drug </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Administration: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Guidance </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Industry: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Evidence-Based </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Review </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>System </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Scientific </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>evaluation </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>health </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>claims. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>[https://www.regulations.gov/docket?D=FDA-2007-D- </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>0371] Retrieved March 5, 2021. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>15.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Huang L, Bai L, Zhang X, and Gong S: Re-understanding </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>antecedents </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>functional </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>foods </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>purchase: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Mediating effect of purchase attitude and moderating </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>effect of food neophobia. </text:span>
<text:span>Food Quality and Preference </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>2019, 73:266–275.
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>16.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Nilova L, Malyutenkova S: Developing the algorithm for </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>assessing the competitive abilities of functional foods in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>marketing. </text:span>
<text:span>SHS Web of Conferences </text:span>
<text:span>2017, 39(01021) </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>17.</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>
<text:s></text:s>
</text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Buckland
<text:s></text:s>
G,
<text:s></text:s>
and
<text:s></text:s>
Gonzalez
<text:s></text:s>
CA:
<text:s></text:s>
The
<text:s></text:s>
role
<text:s></text:s>
of
<text:s></text:s>
olive
<text:s></text:s>
oil
<text:s></text:s>
in </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>disease </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>prevention: </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>A </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>focus </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>on </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>the </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>recent </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>epidemiological </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>evidence </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>from </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>cohort </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>studies </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>and </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>dietary </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>intervention </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>trials. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>The </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>British </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Journal </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>of </text:span>
</text:p>
</draw:text-box>
</draw:frame>
<draw:frame>
<draw:text-box>
<text:p>
<text:span>Nutrition </text:span>
<text:span>2015, 113:94-101. </text:span>
</text:p>
</draw:text-box>
</draw:frame>
</draw:page>
</office:drawing>
</office:body>
</office:document>

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