Natural product inhibitors of acetyl-lysine erasers in the prevention and treatment of heart failure
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Background: Heart failure (HF) is a major public health concern, with five-year mortality rates following first admission for HF being approximately 50%, thereby stressing the need for novel therapeutic approaches. Histone deacetylases (HDACs) govern lysine acetylation of histone tails that regulates nucleosmal DNA. HDAC inhibitors have emerged as efficacious therapies in pre-clinical models of HF. Interest in diet-gene interactions has given rise to the study of ‘food bioactives’ as epigenetic regulators of gene expression that control human health and disease. These reports demonstrate that bioactive food compounds regulate epigenetic marks that link diet to gene regulation. In fact, others have also shown that bioactive compounds can target HDACs for inhibition; accordingly, bioactive food compounds offer unique opportunities for therapeutic intervention and prevention of heart failure. Lastly, there is emerging interest into how these food bioactives function together or as additives within foods ‘functional foods’ to regulate epigenetic disease. This review will highlight bioactive compound HDAC inhibitors and their role in the heart.
Keywords: acetylation, bioactive compounds, dietary HDAC inhibitors, HDACs, histone deacetylases
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Copyright (c) 2017 Bradley S. Ferguson