Effects of taurine intake on serum lipids in young women
Background: Taurine is an abundant amino acid in human cells, promoting ocular and biliary health, which is also used to treat congestive heart failure, hypertension, and hepatitis. Recently, taurine-enriched energy drinks have become popular with young adults, but the effects of taurine on serum lipids in young adults are unknown.
Objective: We studied the influence of oral administration of taurine on serum lipid levels in healthy young women.
Methods: Ten healthy young women with a mean body mass index of 20.0kg/m2, apolipoprotein E (apoE) phenotype 3/3 and normal menstrual cycles participated. Each subject was instructed to orally ingest 1g of taurine powder after each meal (3g/day) in addition to their usual diets during one menstrual cycle. Before and at the end of taurine intake, physical measurements and blood collection were performed in the morning after a 12-h fast, and 3-day weighted dietary records were obtained. Concentrations of serum lipids, apolipoproteins, and fatty acids in the serum phospholipid fraction were measured.
Results: The subjects showed good compliance with taurine intake and none reported adverse effects during the experimental period. After taurine intake, concentrations of total cholesterol, low density lipoprotein cholesterol (LDL-C), free cholesterol, and apolipoprotein B (apoB) increased (p<0.05), while phospholipids tended to increase (p=0.051). Fatty acids in the serum phospholipid fraction also significantly increased (p<0.05). However, triglyceride, remnant-like particle cholesterol, remnant-like particle triglyceride, apoE, the apolipoprotein A-1 (apoA- 1)/apoB ratio and the LDL-C/apoB ratio were unchanged. Furthermore, body weight was significantly increased (p<0.01), but did not correlate with changes either in serum lipids or nutrient intakes.
Conclusion: These results suggest that high taurine intake affects lipoprotein metabolism and increases serum lipids in slightly lean young women.
Key Words: Taurine, slightly lean young women, serum lipids, remnant lipoprotein, fatty acids of the serum phospholipid fraction.
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Copyright (c) 2015 Sadako Matsui, Chizuko Maruyama, Hiroe Arai, Sachie Hashimoto, Tamami Asakusa, Hiroshi Yoshida, Toshitsugu Ishikawa
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